Sergio Stagnaro,
Specialist in Blood, Gastrointestinal, and Metabolic Diseases. Researcher in Biophysical Semeiotics.
Via Erasmo Piaggio 23/8 16037 Riva Trigoso (Genoa) Italy

Send response to journal:
Re: A paramount genetic risk factor, inherited by mother with mDNA, overlooked by WHO

Email Sergio Stagnaro:
dottsergio@libero.it

Sirs,

According to the latest World Health Report, the World Health Organization's annual review of global health, simple measures could increase life expectancy by 5-10 years, only if the war against the top 10 risk factors, besides zinc deficiency and vitamin A deficiency, would be efficaciously more intense (1). As far as risk factors are concerned, such as high blood pressure, smoking, malignancies, and obesity, which are increasingly a global problem even in the developing world, we have to consider, in my opinion, a paramount aetiopathogenetic view-point, i.e., the existence of diverse “constitutions”: diabetic (2), hypertensive, dyslipidemic, rheumatic, oncological, a.s.o., inherited by mother by means of her mitochondrial abnormal DNA, as I illustrated in detail on my site (HONCode 233736, http://digilander.libero.it/semeioticabiofisica) (2, 3).

Exclusively individuals with one or more of these biophysical-semeiotic constitutions, therefore, “can” be involved by the related disorders: e.g., only people with “Oncological Terrain”, who are smokers, can suffer and die for cancers, but surely not other smokers without oncological constitution..

Unfortunately, these epoch-making scientific knowledge is entirely overlooked by the World Health Organization, although my communication, sent by an unanswered e-mail to WHO on March 07, 2002, and reprinted as follows:

To WHO-Geneva and CC NEJM, Piazzetta, Cappellin Solaris, Internetmedicina....

Sirs, please could you answer kindly to my following question?; I certainly will next post this e-mail (with or without your replay: silence clearly is an answer) in the Page, I held weekly in the italian site www.katamed.it): "In your opinion, does it exsist or not the "Oncological Terrain", conditio sine qua non of malignancies, recognizable at the bed side by Biophysical Semeiotics (HONCode N. 233736, http://digilander.iol.it/semeioticabiofisica)?

Many thanks and best regards

Sergio Stagnaro MD Member NYAS
Riva Trigoso (Genoa) Italy

1)Dyer O. Simple measures could increase life expectancy by 5-10 years BMJ 2002;325:985 ( 2 November ).

2)Stagnaro S., Diet and Risk of Type 2 Diabetes. N Engl J Med. 2002 Jan 24;346(4):297-298. letter [PubMed –indexed for MEDLINE].

3)Stagnaro-Neri M., Stagnaro S., Cancro della mammella: prevenzione primaria e diagnosi precoce con la percussione ascoltata. Gazz. Med. It. – Arch. Sc. Med. 152, 447, 1993.

Competing interests:   None declared